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Publications

Research articles

(as first, co- or corresponding author)

• Webster A, Li S, Hur JK, Wachsmuth M, Bois JS, Perkins EM, Patel DJ, and Aravin AA (2015). Aub and Ago3 are recruited to Nuage through two mechanisms to form a ping-pong complex assembled by Krimper. Mol. Cell 59, 565-575.
  
• Wachsmuth M, Conrad C, Bulkescher J, Koch B, Mahen R, Isokane M, Pepperkok R, and Ellenberg J (2015). High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells. Nat. Biotechnol., 33, 384-389.
  
• Boeke D, Trautmann S, Meurer M, Wachsmuth M, Knop M, and Kaksonen M (2014). Quantification of cytosolic interactions identifies Ede1 oligomers as key organizers of endocytosis. Mol. Sys. Biol. 10, 756.
  
• Mahen R, Koch B, Wachsmuth M, Politi AZ, Perez-Gonzalez A, Mergenthaler J, Cay Y, and Ellenberg J (2014). Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells. Mol. Biol. Cell. 25, 3610-3618.
  
• Baum M, Erdel F, Wachsmuth M, and Rippe K (2014). Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells. Nat. Comm. 5, 4494.
• Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Manley S, and Gönczy P (2014). HsSAS-6 oligomerization promotes centriole formation in human cells. J. Cell Biol. 204, 697-712.
  
• Im K-B, Schmidt U, Kang MS, Lee JY, Bestvater F, and Wachsmuth M (2013). Diffusion and binding analysed with combined point FRAP and FCS. Cytometry A 89, 876-889.
  
• Skruzny M, Brach T, Ciuffa R, Rybina S, Wachsmuth M, and Kaksonen M (2012). Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis. Proc. Natl. Acad. Sci. USA 109, E2533-E2542.
• Khmelinski A, Keller PJ, Bartosik A, Meurer M, Barry JD, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E, and Knop M (2012). Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nat. Biotechnol. 30, 708-714.
  
• Capoulade J, Wachsmuth M, Hufnagel L, and Knop M (2011). Quantitative imaging of fluorescent protein diffusion and interaction inside cells. Nat. Biotechnol. 29, 835-839.
• Erdel F, Müller-Ott K, Baum M, Wachsmuth M, and Rippe K (2011). Dissecting chromatin interactions in living cells from protein mobility maps. Chromosome Res. 19, 99-115.
• Im K-B, Kang M-S, Kim J, Bestvater F, Seghiri Z, Wachsmuth M, and Grailhe R (2010). Two-photon spectral imaging with high temporal and spectral resolution. Optics Express 18, 26905-26914.
• Bestvater F, Seghiri Z, Kang MS, Gröner N, Lee JY, Im K-B, and Wachsmuth M (2010). EMCCD-based spectrally resolved fluorescence correlation spectroscopy. Optics Express 18, 23818-23828.
• Gröner N, Capoulade J, Cremer C, and Wachsmuth M (2010). Measuring and imaging diffusion with multiple scan speed image correlation spectroscopy. Optics Express 18, 21225-21237.
• Müller KP, Erdel F, Caudron-Herger M, Marth C, Fodor BD, Richter M, Scaranaro M, Beaudouin J, Wachsmuth M, and Rippe K (2009). Multiscale Analysis of Dynamics and Interactions of Heterochromatin Protein 1 by Fluorescence Fluctuation Microscopy. Biophys. J. 97, 2876-2885.
• Heuvelman G, Erdel F, Wachsmuth M, and Rippe K (2009). Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy. Eur. Biophys. J. 38, 813-828.
• Schmidt U, Im K-B, Benzing C, Janjetovic S, Rippe K, Lichter P, and Wachsmuth M (2009). Assembly and mobility of exon-exon junction complexes with mRNA in the nucleus. RNA 15, 862-876.
• Jegou T, Chung I, Heuvelmann G, Wachsmuth M, Görisch SM, Greulich-Bode K, Boukamp P, Lichter P and Rippe K (2009). Dynamics of telomeres and PML nuclear bodies in a telomerase negative human cell line. Mol Biol Cell 20, 2070-2082.
• Mozziconacci J, Sandblad L, Wachsmuth M, Brunner D, and Karsenti E (2008). Tubulin Dimers Oligomerize before Their Incorporation into Microtubules. PLoS ONE 3, e3821.
• Dusch E, Dorval T, Vincent N, Wachsmuth M, and Genovesio A (2007). Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective. J. Microsc. 228: 132-138.
• Strohner R, Wachsmuth M, Dachauer K, Mazurkiewicz J, Hochstätter J, Rippe K, and Längst G (2005). A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling. Nat. Struct. Mol. Biol. 12, 683-690.
• Görisch SM, Wachsmuth, M, Fejes Tóth K, Lichter P, and Rippe K (2005). Histone acetylation increases chromatin accessibility, J. Cell Sci. 118, 5825-5834.
• Sommer P, Vartanian JP, Wachsmuth M, Henry M, Guetard D, and Wain-Hobson, S (2004). Anti-termination by SIV Tat requires flexibility of the nascent TAR structure. J. Mol. Biol. 344, 11-28.
• Módos K, Galántai R, Bárdos-Nagy I, Wachsmuth M, Tóth K, Fidy J, and Langowski J (2004). Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association. Eur. Biophys. J. 33, 59-67.
• Görisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, and Lichter P (2004). Nuclear body movement is determined by chromatin accessibility and dynamics. Proc. Nat. Acad. Sci. USA 101, 13221-13226.
• Fejes Tóth K, Knoch TA, Wachsmuth M, Stöhr M, Frank-Stöhr M, Bacher CP, Müller G, and Rippe K (2004). Trichostatin A induced histone acetylation causes decondensation of interphase chromatin. J. Cell Sci. 117, 4277-4287.
• Weidemann T, Wachsmuth M, Knoch TA, Müller G, Waldeck W, and Langowski J (2003). Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging. J. Mol. Biol. 334, 229-240.
• Wachsmuth M, Weidemann T, Müller G, Hoffmann-Rohrer UW, Knoch TA, Waldeck W, and Langowski J (2003). Analyzing Intracellular Binding and Diffusion with Continuous Fluorescence Photobleaching. Biophys. J. 84, 3353-3363.
• Braun K, Peschke P, Pipkorn R, Lampel S, Wachsmuth M, Waldeck W, Friedrich E, and Debus J (2002). A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells. J. Mol. Biol. 318, 237-243.
• Wachsmuth M, Waldeck W, and Langowski J (2000). Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. J. Mol. Biol. 298, 677-689.

Review articles

• Wachsmuth M. (2014). Molecular diffusion and binding studied with FRAP. Protoplasma 251, 373-382.
  
• Wachsmuth M, Caudron-Herger M, and Rippe K. (2008). Genome organization: balancing stability and plasticity. Biochim. Biophys. Acta 1783, 2061-2079.
• Weidemann T, Wachsmuth M, Tewes M, Rippe K, and Langowski J (2002). Analysis of ligand binding by two-colour fluorescence cross-correlation spectroscopy. Single Molecules 3, 49-61.

Book chapters

• Capoulade J, Reynaud EG, and Wachsmuth M (2013). Imaging marine life with a thin light-sheet. In: Imaging Marine Life – Modern Imaging Techniques in Marine Biology (ed. Reynaud EG), Wiley, Weinheim.
  
• Wachsmuth M, and Weisshart K (2007). Fluorescence photobleaching and fluorescence correlation spectroscopy: two complementary technologies to study molecular dynamics in living cells. In: Imaging Cellular and Molecular Biological Functions (eds. Shorte S, and Frischknecht F), Springer Verlag, Heidelberg.
• Langowski J, Wachsmuth M, Rippe K, and Tewes M (2000). Biomolecular shape and interactions determined by fluorescence correlation spectroscopy. In: Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif (ed. Frénoy J-P), Publications CNRS, Paris.

Patents

• Wachsmuth M, Capoulade J, and Knop M (2011). Light-pad microscope for high-resolution 3D fluorescence imaging and 2D fluctuation spectroscopy. US Patent Application US 6144 2616.
• Wachsmuth M, Heuvelman G, and Rippe K (2006). Vorrichtung zur multifokalen konfokalen mikroskopischen Bestimmung der räumlichen Verteilung und zur multifokalen Fluktuationsanalyse von fluoreszenten Molekülen und Strukturen mit spektral flexibler Detektion. German Patent DE 10 2005 000 915.
• Wachsmuth M (2005). Verfahren zur Messung von Fluoreszenzkorrelationen in Gegenwart von langsamen Signalschwankungen. German Patent DE 103 27 531.
• Wachsmuth M (2005). Vorrichtung zur Bestimmung gerichteter Transportprozesse. German Patent DE 103 27 531.
• Wachsmuth M, and Langowski J (2002). Fluoreszenzfluktuationsmikroskop, -messmodul bzw. –scanmodul und Verfahren zur Fluoreszenzfluktuationsmessung. German Patent DE 101 22 046.

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